HIV Aids Words in a Puzzle

When 46-year-old Timothy Brown was the first person to be cured of HIV in 2007, it was a huge medical breakthrough.  It was also a breakthrough made possible thanks to the unique regenerative capabilities of stem cells.

Mr Brown was being treated for leukaemia and received umbilical cord stem cell transplant to beat it.  The result was remarkable — he was cured of HIV.

Doctors realised that the bone marrow he received came from a donor with a genetic mutation that made him immune from HIV.   The “delta 32” mutation occurs in an estimated 1 per cent of the population, primarily in those descended from Northern European races.

In subsequent years researchers have realised that the key to curing HIV may come from stem cells and not from drugs.  The problem is the fact that it can be difficult to find the close genetic match needed so stem cell transplants aren’t rejected.

This is where umbilical cord stem cells come in.  The match between donor and recipient does not need to be as close when using umbilical cord blood stem cells.  That is because the stem cells in umbilical cord blood are at a young stage and not closely linked to a particular genetic profile.

The next hurdle is the fact that umbilical cord blood samples with the genetic mutation are quite rare.  Out of 17,000 umbilical cord blood samples tested, only 102 carried the mutation that could cure HIV.

The solution for this might come from other research.  A recent research paper suggests that a molecule might be capable of helping umbilical cord stem cells multiply.   Researchers from the Institute for Research in Immunology and Cancer (IRIC) discovered that the molecule (named UM171) helped umbilical cord stem cells multiply.

By taking an umbilical cord sample with the genetic mutation and multiplying it, researchers may be able to produce enough stem cells to rid the world of HIV.  Stem cells are once again at the forefront of exciting new medical research projects.

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