BGI SENTIS™ Hereditary Breast and Ovarian Cancer Panel

Introduction

BGI’s hereditary risk screening cancer panels target genes previously linked to a predisposition of cancer. Panel selection was based on expert curation of scientific literature and other high quality resources, including formal medical guidelines.

BGI’s Hereditary Breast and Ovarian (HBOC) panel provides health providers  with information on 21 genes associated with Hereditary Breast and Ovarian Cancer (HBOC) based on recent scientific and clinical literature. BGI detects different alterations including germline SNV, Indels and CNVs.

SUITABLE FOR

Patients suspected of being at increased risk of HBOC

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TA TIME

20 working days

SAMPLE

Peripheral blood, DNA, Saliva

TECHNOLOGY

Target region capture, high-throughput sequencing

Panels and Genes

TEST LIST

GENE LIST

Sentis BRCA (2 genes) panel

BRCA1, BRCA2

Sentis Hereditary Breast and Ovarian (21 genes) panel

BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1,NBN, MRE11A,MSH2, MSH6, MUTYH, PMS1,PMS2, RAD50, RAD51C

Why Choose the BGI SENTIS™ – Hereditary Breast and Ovarian Cancer Panel?

  • Comprehensive – whole exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications, rearrangements
  • Robust – clinically important (pathogenic or likely pathogenic) variants are verified by Sanger Sequencing while large gene rearrangements are verified by qPCR
  • Convenient – test from blood or saliva; DNA is also accepted
  • Professional – state-of-the-art variant database ensures up-to-date analysis and interpretation.

Note: this test is considered a screening test, not a diagnostic test. Before making any treatment decisions, all patients should discuss their results with their healthcare provider, who can recommend confirmatory, diagnostic testing where appropriate. This testing service has not been cleared or approved by the US FDA and is not available in the USA.

Workflow

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STEP 1

Counselling and consent

STEP 2

Sample collection

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STEP 3

Sample shipped to BGI and analyzed

STEP 4

Report and Genetic counselling

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